99% Purity Dihexa Peptide APIs White Powder CAS 1401708-83-5 with cheap price

1401708-83-5 Dihexa

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99% Purity Dihexa Peptide APIs White Powder CAS 1401708-83-5 with cheap price

Product Name: Dihexa
Synonyms: Dihexa;Hexanoyl-Tyr-Ile-Ahx-NH2;N-hexanoic-Try-Ile-(6)-amino hexanoic amide;PNB-0408;Dihexa (PNB-0408);N-(1-OXOHEXYL)-L-TYROSYL-N-(6-AMINO-6-OXOHEXYL)-L-ISOLEUCINAMIDE;L-Isoleucinamide, N-(1-oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-
CAS: 1401708-83- 5
MF: C27H44N4O5
MW: 504.66
EINECS: 227-005-2
Product Categories:  
Mol File:

1401708-83- 5






Description Dihexa (developmental code name PNB-0408), also known as N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, is an oligopeptide drug derived from angiotensin IV that binds with high affinity to hepatocyte growth factor (HGF) and potentiates its activity at its receptor, c-Met. The compound has been found to potently improve cognitive function in animal models of Alzheimer's disease-like mental impairment. In an assay of neurotrophic activity, Dihexa was found to be seven orders of magnitude more potent than brain-derived neurotrophic factor.
Uses N-Hexanoic-Try-Ile-(6)-amino Hexanoic amide (Dihexa) is an angiotensin IV analog as a procognitive/antidementia agent.
Uses Dihexa, an oligopeptide drug, is an orally active and blood-brain barrier-permeable angiotensin IV analog. Dihexa binds to hepatocyte growth factor (HGF) with high affinity (Kd=65 pM) and potentiates its activity at its receptor, c-Met. Dihexa exhibits excellent antidementia activity and improves cognitive function in animal models. Dihexa may have therapeutic potential as a treatment Alzheimer’s disease.
benefits As a new drug, Dihexa has been highly seen to help people experiencing Alzheimer's Disease.
Thus, it's main function is to relieve and supplement people who are stricken by this Disease to slow down the progression of Alzheimer's.
The best thing about Dihexa is its ability to be able to repair damages found in the synapse that is just between the neurons.
Here are some of the benefits of Dihexa:
Helps people having Alzheimer's Disease and those with Parkinson's Disease
Can increase your mental stamina
Can improve creative thinking skills
Can enhance conversational skills
Can improve one's ability to solve problems
Can help in managing depression
Improves memory
Dihexa also helps one improve focus and learning. That's why this is good most, especially for people who study too.
It can even improve heart health, and also boost medical endurance.
People who use Dihexa have had testimonies of how this peptide has helped improve their creativity, thinking, and even problem-solving skills.
Although you must keep in mind that despite the benefits of Dihexa, it still has some side effects that you must be aware of primarily when it is being regularly used.
One who even stops using Dihexa can have severe withdrawal effects once they decide to discontinue using this peptide. Some side effects could be unexpected jitters or even irritability.
Biological Activity Dihexa is an orally active, blood-brain barrier-permeable angiotensin IV analog; exhibits high affinity binding hepatocyte growth factor (HGF) with a Kd of 65 pM.
Dihexa binds with high affinity to HGF and both dihexa and its parent compound Norleucine 1-AngIV induce c-Met phosphorylation in the presence of subthreshold concentrations of HGF and augment HGF-dependent cell scattering. Further, dihexa and Nle1-AngIV induce hippocampal spinogenesis and synaptogenesis similar to HGF itself. Dihexa effectively inhibits HGF dimerization at 1 μM. While dihexa at 1 nM and 10 pM alone does not activate c-Met, it markedly augments the capacity of HGF at 1.25 and 2.5 ng/mL to activate c-Met.
Dihexa has a long circulating half-life. Dihexa exhibits procognitive activity. Dihexa reverses scopolamine-dependent spatial learning deficits. It improves spatial learning in aged rats. Dihexa induces spinogenesis in cultured hippocampal neurons.
Clinical Use Dihexa is a peptide variant derived from angiotensin IV which has been found to potently improve cognitive function in animal models of disease such as Alzheimer’s. Angiotensin IV is a derivative of the potent vasoconstrictor angiotensin II and has been shown to enhance acquisition, consolidation, and recall of learning and memory in animal models when administered centrally or peripherally. In an essay of neurotrophic activity, Dihexa was found to be seven orders of magnitude more potent than BDNF. It could possibly help in the repair of the brain and nerves in neurological disease.
Mode of action Being a first-class compound that is orally active, Dihexa works through penetrating the blood-brain barriers. This also works through facilitating one's memory consolidation and even memory retrieval.
Researchers have seen how this peptide is very active. It also shows a very promising characteristic in terms of overcoming any memory and motor dysfunction.

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A: Yes, we welcome sample order to test and check quality. Mixed samples are acceptable. We provide free samples, but the freight will be borne by you, and the cost will be returned to you or deducted from your order later.
Q2. What about the lead time?
A:Sample needs 3-5 days, mass production time needs 1-2 weeks for order quantity more than
Q3. Do you have any MOQ limit for order?
A: Low MOQ, 10-100g for sample checking is available
Q4. How do you ship the goods and how long does it take to arrive?
A: We usually ship by DHL, UPS, FedEx or TNT. It usually takes 3-5 days to arrive. Airline and sea shipping also optional.
Q5. How about the packing?
A: Usually we provide the packing as 25 kg / bag or carton. Of course, if you have special requirements on them, we will according to you.
Q6: how do you control quality?
A: We will make samples before mass production and start mass production after sample approval. 100% inspection during production and random inspection before packaging.
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Q9: can you give me a discount?
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A: you can get free samples for some products. You only need to pay for transportation or arrange express delivery to take samples for us. You can send us your product specifications and requirements. We will make products according to your requirements.
Q11: how do you deal with quality complaints?
A: first of all, our quality control will reduce the quality problem to nearly zero. If the actual quality problem is caused by
us, we will send you free goods for replacement or refund.
Q12: Are you trading company or manufacturer?
A: We are chemical factory in China. So we can provide wholesale price.


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