Whatsapp+8615512120776 Fast and safe delivery 99% Purity Cetuximab 205923-56-4

Cetuximab 205923-56-4 / whatsapp +8615512120776

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Product Description

 

Fast and safe delivery 99% Purity Cetuximab 205923-56-4

Factory Supply Antiviral API 99% CAS 259793-96-9 Favipiravir Powder with Fast and Safe Delivery


Cetuximab, a human/mouse chimeric monoclonal antibody that blocks the EGFR, was launched for use in combination with irinotecan in the treatment of patients with colorectal cancer who no longer respond to standard chemotherapy treatment with irinotecan. Cetuximab is obtained by chimerization of M225, a murine anti-EGFR antibody; specifically heavy and light chains of the murine antibody are cloned and adapted for expression with constant regions of the human kappa light chain and human gamma1 heavy chain. It is produced by mammalian (suspension) cells in serum-free medium, purified by protein A affinity chromatography, ion-exchange chromatography, and gel filtration. Cetuximab binds specifically to EGFR on both normal and tumor cells. Overexpression of the human EGFR is detected in many cancers, including those of the colon and rectum. The binding of cetuximab to EGFR prevents growth factors from binding to the receptor, thereby inhibiting cell growth and inducing apoptosis. The therapeutic regimen of cetuximab consists of an initial loading dose of 400 mg/m2 administered as a 120-min IV infusion, followed by weekly maintenance dose of 250 mg/m2 infused over 60 min. The steady-state plasma concentrations of cetuximab are reached by the third weekly infusion and the mean elimination half-life is 114 h. Cetuximab is eliminated by binding to EGFRs in various tissues, followed by internalization of the antibody- EGFR complex. Systemic clearance of the antibody is saturated at higher doses, and this appears to correlate with saturation of EGFR binding. In a multicenter clinical trial in more than 300 patients with advanced metastatic colorectal cancer, combination therapy with cetuximab and irinotecan produced response in more than half of the patients, shrinking tumors in 23% and stopping tumor growth in an additional 33% of the patients. The most common adverse reactions associated with cetuximab were acneform rash, asthenia/malaise, fever, nausea, abdominal pain, constipation and vomiting. Serious adverse events such as infusion reaction, fever, sepsis, kidney failure, dehydration and diarrhea were experienced by <10% of the patients.

 

Product Name: CETUXIMAB
Synonyms: CETUXIMAB;Hsdb 7454;Immunoglobulin G1, anti-(human epidermal growth factor receptor) (human-mouse monoclonal C225 gamma1-chain), disulfide with human-mouse monoclonal C225 kappa-chain, dimer;Unii-pqx0D8J21j;CetuxiMab(C225);EGFR antibody;IMC 225;Cetuximab - Buffer solution
CAS: 205923-56-4
MF: C107H179N35O36S7
MW: 2756.23406

Factory Supply Antiviral API 99% CAS 259793-96-9 Favipiravir Powder with Fast and Safe DeliveryFactory Supply Antiviral API 99% CAS 259793-96-9 Favipiravir Powder with Fast and Safe Delivery

Factory Price 4-Methyl-2-Pentanamine Hydrochloride / 1, 3-Dimethylbutylamine Hydrochloride CAS 71776-70-0

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Our company is located in the center of politics, military, economy, culture and science and education in South China.We are a professional manufacturer engaged in the research, development, production, sales and service of surfactants, biological agents, organic chemistry, oilfield chemicals and disinfectant raw materials.We can offer a wide range of products to meet the changing needs of the market.Custom orders are welcome.We are committed to strict quality control and thoughtful customer service, and our experienced staff are always available to discuss your requirements and ensure complete customer satisfaction.With an annual production capacity of 10,000 tons/year, we can easily meet your large orders.If you are interested in any of our products or would like to place a custom order, please contact us.We will do our best to meet your needs.

FAQ

Q1. Can I have a sample order for your products?
A: Yes, we welcome sample order to test and check quality. Mixed samples are acceptable. We provide free samples, but the freight will be borne by you, and the cost will be returned to you or deducted from your order later.
Q2. What about the lead time?
A:Sample needs 1-3 days, mass production time needs 1-2 weeks.
Q3. Do you have any MOQ limit for order?
A: Low MOQ, 10-100g for sample checking is available
Q4. How do you ship the goods and how long does it take to arrive?
A: We usually ship by DHL, UPS, FedEx or TNT. It usually takes 3-5 days to arrive. Airline and sea shipping also optional.
Q5. How about the packing?
A: Usually we provide the packing as 25 kg / bag or carton. Of course, if you have special requirements on them, we will according to you.
Q6: how do you control quality?
A: We will make samples before mass production and start mass production after sample approval. 100% inspection during production and random inspection before packaging.
Q7: how to contact us?
A: Pls send us the product information you are interested in. You will get a reply within 24hours.
Q8: which payment method do you accept?
A: For small orders, you can pay by wire transfer, Western Union, Moneygram transfer, Bank Tansfer, Bitcoin or Alibaba.
Q9: can you give me a discount?
A: Of course, it depends on your quantity
Q10: how to confirm product quality before placing an order?
A: you can get free samples for some products. You only need to pay for transportation or arrange express delivery to take samples for us. You can send us your product specifications and requirements. We will make products according to your requirements.
Q11: how do you deal with quality complaints?
A: first of all, our quality control will reduce the quality problem to nearly zero. If the actual quality problem is caused by
us, we will send you free goods for replacement or refund.
Q12: Are you trading company or manufacturer?
A: We are chemical factory in China. So we can provide wholesale price.

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