Sample Available Pure Powder Sofosbuvir CAS 1190307-88-0 From Wanjiang

C22H29FN3O9P CAS NO.1190307-88-0 Sofosbuvir / whatsapp +8615512120776

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Product Description

 

Factory Direct Supply 99% purity pharmaceutical intermediate Sofosbuvir CAS 1190307-88-0

Factory Supply Antiviral API 99% CAS 259793-96-9 Favipiravir Powder with Fast and Safe Delivery

Sofosbuvir is a pyrimidine nucleotide analogue (Fig. 1) that inhibits HCV NS5B RNA-dependent RNA polymerase, which is essential for viral replication[11, 12], Sofosbuvir is a prodrug that undergoes intracellular metabolism in human hepatocytes to a pharmacologically active uridine triphosphate form (GS-461203)[11-14]. GS-461203 is incorporated into HCV RNA by NS5B polymerase where it acts as a chain terminator[11, 12]. In vitro, the GS-461203 concentration leading to 50 % inhibition of the polymerase activity of recombinant NS5B from HCV genotype 1b, 2a, 3a and 4a ranged from 0.7 to 2.6 micromolar per liter. A rapid rate of viral decline was seen with Sofosbuvir[20]. It was estimated that 99 and 99.9 % of final effectiveness would be reached in a mean 0.8 and 2 days, respectively[20]. HCV RNA levels declined in a biphasic manner[20].
Sofosbuvir has a high genetic barrier to resistance[15]. Studies have found that resistance-associated variants (including the primary sofosbuvir resistance mutation in NS5B, S282T) were not detected in any patient receiving sofosbuvir in combination with ribavirin with or without peginterferon-alpha[15, 16]. However, the S282T resistance mutation was detected in one patient with HCV genotype 2b infection who received sofosbuvir monotherapy. Although L159F and V321A substitutions were detected in some patients with HCV genotype 3a infection who received sofosbuvir-containing regimens in phase III trials, these substitutions were not associated with changes in phenotypic susceptibility of sofosbuvir[12]. In patients with HCV genotype 1a or 2b infection and HCC who received sofosbuvir and ribavirin for up to 48 weeks while awaiting liver transplantation, the L159F substitution emerged in multiple patients who experienced virological failure (breakthrough and relapse)[12]. The presence of L159F and/or C316N substitutions at baseline was also associated with post-transplant virological breakthrough and relapse in multiple patients with HCV genotype 1b infection[12].
HCV replicons expressing the S282T resistance mutation showed low level resistance to sofosbuvir, but retained susceptibility to ribavirin and other classes of direct-acting antivirals, including NS5A inhibitors[17]. Sofosbuvir retained full activity against the nucleoside inhibitor resistance-associated variants L159F and L320F, the ribavirin resistance-associated variants T390I and F415Y, and against clinically relevant protease inhibitor, non-nucleoside inhibitor and NS5A inhibitor resistance-associated variants[18, 19]

 

 

Product Name: Sofosbuvir
Synonyms: (S)-isopropyl 2-(((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-Methyltetrahydrofuran-2-yl)Methoxy)(phenoxy)phosphoryl)aMino)propanoate;PSI-7977 Discontinued;L-Alanine, N-[[P(S),2'R]-2'-deoxy-2'-fluoro-2'-Methyl-P-phenyl-5'-uridylyl]-, 1-Methylethyl ester;Sophy Bouvet;Sofosbuvir and intermediates;Sofosbuvir1190307-88-0;Isopropyl (2S)-2-{[(S)-{[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl)-4-fluoro-3-hydroxy-4-methyltetrahydro-2-furanyl]methoxy}(phenoxy)phosphoryl]amino}propanoate;PSI-7977;GS-7977;PSI 7977;GS 7977;SOFOSBUVIR
CAS: 1190307-88-0
MF: C22H29FN3O9P
MW: 529.45
EINECS: 695-717-4
Factory Price 4-Methyl-2-Pentanamine Hydrochloride / 1, 3-Dimethylbutylamine Hydrochloride CAS 71776-70-0
 

 

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Our company is located in the center of politics, military, economy, culture and science and education in South China.We are a professional manufacturer engaged in the research, development, production, sales and service of surfactants, biological agents, organic chemistry, oilfield chemicals and disinfectant raw materials.We can offer a wide range of products to meet the changing needs of the market.Custom orders are welcome.We are committed to strict quality control and thoughtful customer service, and our experienced staff are always available to discuss your requirements and ensure complete customer satisfaction.With an annual production capacity of 10,000 tons/year, we can easily meet your large orders.If you are interested in any of our products or would like to place a custom order, please contact us.We will do our best to meet your needs.

FAQ

Q1. Can I have a sample order for your products?
A: Yes, we welcome sample order to test and check quality. Mixed samples are acceptable. We provide free samples, but the freight will be borne by you, and the cost will be returned to you or deducted from your order later.
Q2. What about the lead time?
A:Sample needs 1-3 days, mass production time needs 1-2 weeks.
Q3. Do you have any MOQ limit for order?
A: Low MOQ, 10-100g for sample checking is available
Q4. How do you ship the goods and how long does it take to arrive?
A: We usually ship by DHL, UPS, FedEx or TNT. It usually takes 3-5 days to arrive. Airline and sea shipping also optional.
Q5. How about the packing?
A: Usually we provide the packing as 25 kg / bag or carton. Of course, if you have special requirements on them, we will according to you.
Q6: how do you control quality?
A: We will make samples before mass production and start mass production after sample approval. 100% inspection during production and random inspection before packaging.
Q7: how to contact us?
A: Pls send us the product information you are interested in. You will get a reply within 24hours.
Q8: which payment method do you accept?
A: For small orders, you can pay by wire transfer, Western Union, Moneygram transfer, Bank Tansfer, Bitcoin or Alibaba.
Q9: can you give me a discount?
A: Of course, it depends on your quantity
Q10: how to confirm product quality before placing an order?
A: you can get free samples for some products. You only need to pay for transportation or arrange express delivery to take samples for us. You can send us your product specifications and requirements. We will make products according to your requirements.
Q11: how do you deal with quality complaints?
A: first of all, our quality control will reduce the quality problem to nearly zero. If the actual quality problem is caused by
us, we will send you free goods for replacement or refund.
Q12: Are you trading company or manufacturer?
A: We are chemical factory in China. So we can provide wholesale price.

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