Camptotheca Acuminata Extract/Camptothecin of 98% 10-Hydroxycamptothecin Camptothecin (CPT)

Camptothecin Powder CAS 7689-03-4/ whatsapp +8615512120776

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Product Description

Manufacturer supply High Quality Anti Cancer 99% Camptothecin Powder CAS 7689-03-4

 

Anti Cancer Anti Oxidant Camptothecin CAS 7689-03-4

Anti Cancer 98% Camptothecin Powder CAS 7689-03-4

 

Product name (+)-Camptothecin
Specification

98% HPLC

Appearance

Yellow Powder

Latin Name

Camptotheca acuminata Decne.sp

Part of Used

Leaves & Fruits

CAS

7689-03-4

M.F.

C20H16N2O4

Total Heavy Metals  ≤10ppm Loss on Drying  ≤ 5%
Mesh size  95% pass 80 mesh Sheliflife  2 Years

 

Camptothecin (CPT) is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme topoisomerase I (topo I). It was discovered in 1966 by M. E. Wall and M. C. Wani in systematic screening of natural products for anticancer drugs. It was isolated from the bark and stem of Camptotheca acuminata (Camptotheca, Happy tree), a tree native to China used as a cancer treatment in Traditional Chinese Medicine. CPT showed remarkable anticancer activity in preliminary clinical trials but also low solubility and (high) adverse drug reaction. Because of these disadvantages synthetic and medicinal chemists have developed numerous syntheses of Camptothecin and various derivatives to increase the benefits of the chemical, with good results. Two CPT analogues have been approved and are used in cancer chemotherapy today, topotecan and irinotecan.


Anti Cancer 98% Camptothecin Powder CAS 7689-03-4

 

 


Function:
1.Camptothecin and its derivatives are unique in their ability to inhibit DNA Topoisomerase I, by stabilizing a covalent reaction intermediate termed the cleavable complex which ultimately causes tumor cell death.
2.In clinical it is widely believed that camptothecin analogs exhibited remarkable anti-tumour and anti- leukaemia activity. Topoisomerase is a basilic enzyme in the process of DNA replication, it is responsible for the winding /unwinding of the supercoiled DNA composing the chromosomes. If the chromosomes cannot be unwound, transcription of DNA message cannot occur and the protein cannot be synthesized, it ultimately causes cell death.
3.Application of camptothecin in clinic is limited due to serious side effects and poor water-solubility.
4.At present, some camptothecin analogs,either semi-synthetic or synthetic drug based on camptothecin, have been applied cancerous therapy such as topotecan and irinotecan while others have been obtained satisfying curative effects in clinic.


Application:
1.Camptothecin can make changes in skin epidermal keratinization process.
2.Camptothecin is used for anti-cancer, anti-virus, immune inhibition, anti early pregnancy.
3.Camptothecin has the function of treatment of gastric cancer, liver cancer, head and neck cancer and
leukemia,with fewer side effects than camptothecine.

 

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Our company is located in the center of politics, military, economy, culture and science and education in South China.We are a professional manufacturer engaged in the research, development, production, sales and service of surfactants, biological agents, organic chemistry, oilfield chemicals and disinfectant raw materials.We can offer a wide range of products to meet the changing needs of the market.Custom orders are welcome.We are committed to strict quality control and thoughtful customer service, and our experienced staff are always available to discuss your requirements and ensure complete customer satisfaction.With an annual production capacity of 10,000 tons/year, we can easily meet your large orders.If you are interested in any of our products or would like to place a custom order, please contact us.We will do our best to meet your needs.

FAQ

Q1. Can I have a sample order for your products?
A: Yes, we welcome sample order to test and check quality. Mixed samples are acceptable. We provide free samples, but the freight will be borne by you, and the cost will be returned to you or deducted from your order later.
Q2. What about the lead time?
A:Sample needs 1-3 days, mass production time needs 1-2 weeks.
Q3. Do you have any MOQ limit for order?
A: Low MOQ, 10-100g for sample checking is available
Q4. How do you ship the goods and how long does it take to arrive?
A: We usually ship by DHL, UPS, FedEx or TNT. It usually takes 3-5 days to arrive. Airline and sea shipping also optional.
Q5. How about the packing?
A: Usually we provide the packing as 25 kg / bag or carton. Of course, if you have special requirements on them, we will according to you.
Q6: how do you control quality?
A: We will make samples before mass production and start mass production after sample approval. 100% inspection during production and random inspection before packaging.
Q7: how to contact us?
A: Pls send us the product information you are interested in. You will get a reply within 24hours.
Q8: which payment method do you accept?
A: For small orders, you can pay by wire transfer, Western Union, Moneygram transfer, Bank Tansfer, Bitcoin or Alibaba.
Q9: can you give me a discount?
A: Of course, it depends on your quantity
Q10: how to confirm product quality before placing an order?
A: you can get free samples for some products. You only need to pay for transportation or arrange express delivery to take samples for us. You can send us your product specifications and requirements. We will make products according to your requirements.
Q11: how do you deal with quality complaints?
A: first of all, our quality control will reduce the quality problem to nearly zero. If the actual quality problem is caused by
us, we will send you free goods for replacement or refund.
Q12: Are you trading company or manufacturer?
A: We are chemical factory in China. So we can provide wholesale price.

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