Factory Supply Pharmaceutical Intermediate Raw Material CAS 2398-96-1 Tolnaftate Powder for Onychomycosis Treatment

2398-96-1 Tolnaftate. wickr : wjadmin whatsapp +86 15512120776

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Biological Agents   Chemical Enterprise

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Sales manager:Anna Sofia
 
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Product Description
Factory Supply Pharmaceutical Intermediate Raw Material CAS 2398-96-1 Tolnaftate Powder for Onychomycosis Treatment

 

Product Description

Tolnaftate is an old synthetic topical thiocarbamate antifungal agent with the chemical name 2-naphthyl N-methyl-N-(3-tolyl)thlonocarbamate; the chemical structure is shown below. Clinical use of tolnaftate has declined with the introduction of more potent antifungal compounds such as terbinafine and naftifine. 


Uses
Tolnaftate is used primarily for the treatment of mild to moderate tinea pedis, tinea cruris, tinea corporis, and tinea versicolor. It is not indicated for the treatment of onychomycosis due to the lack of drug penetration through the nail plate. Tolnaftate has been successfully used in the treatment of fungal otitis externa; however, it is not recommended for the treatment of serious fungal infections.

Mechanism of action
Like naftifine and terbinafine , tolnaftate is a reversible and noncompetitive inhibitor of fungal squalene epoxidase. The blockade of this enzyme results in the accumulation of squalene and a deficiency of ergosterol, the major component of fungal cell membrane. 

In T. mentagrophytes cells, tolnaftate has been shown to cause a dosedependent inhibition of ergosterol biosynthesis and accumulation of squalene. Complete inhibition was achieved at concentrations of 0.1 mg/ml. In contrast, the activity of tolnaftate against C. albicans and C. parapsilosis was notably lower, and incomplete inhibition was achieved only at concentrations of 100 mg/ml. The activity of tolnaftate on sterol biosynthesis was enhanced in a cell-free system of C. albicans, suggesting that tolnaftate might be unable to diffuse into the cell envelope of Candida spp. The comparative potency of the thiocarbamates and allylamines for the microsomal squalene epoxidase of T. rubrum and C. albicans was explained by the affinity of the antifungal agents for the squalene epoxidase. 

In this regard, tolnaftate has a much higher specificity for the T. rubrum squalene epoxidase than for the enzyme of C. albicans.

Dosage  
Tolnaftate is available as a 1% lotion, cream, aerosol spray, and powder. For tinea pedis and tinea cruris, 1% cream, solution, or powder is applied twice daily for 2-6 weeks. It is recommended that tolnaftate application should be extended at least 2 cm beyond the visible edge of the tinea lesion, and the cream or lotion should be rubbed gently into the area.

Uses  
Tolnaftate 1% cream applied twice daily for 3 or 4 weeks is as effective as clotrimazole 1% cream for the treatment of tinea pedis, tinea corporis, and tinea cruris due to T. rubrum, T. mentagrophytes, and E. floccosum. Mycologic eradication was demonstrated in 93% of tolnaftate-treated patients and clinical cure was achieved in 53-70% of patients in small studies. No relapse was documented in the 4 weeks' follow-up treatment. 

Equivalent mycologic and clinical efficacy (65-70%) was documented for tolnaftate 1% cream, 3% undecylenic acid, and 20% zinc undecylenate as a cream. A randomized, controlled study comparing 10% tea tree oil cream, 1% tolnaftate cream, and placebo in the treatment of tinea pedis showed similar clinical efficacy with tea tree oil and tolnaftate; however, 1% tolnaftate cream was significantly more effective in achieving a mycologic cure (85% mycologic cure in the tolnaftate arm versus 30% in the tea tree oil arm).

Side effects 
Skin irritation and contact dermatitis have been rarely reported.
 

 


Function
1.Tolnaftate is a synthetic over-the-counter anti-fungal agent. It may come as a cream,
powder, spray, or liquid aerosol, and is used to treat jock itch, athlete's foot and ringworm.

2.Tolnaftate topical is used to treat skin infections such as athlete's foot, jock itch, and
ringworm infections. Tolnaftate is also used, along with other antifungals, to treat infections
of the nails, scalp, palms, and soles of the feet. The powder and powder aerosol may be used
to prevent athlete's foot.

3.Tolnaftate is a topical fungicide. Though its exact mechanism unknown, it is believed to
prevent ergosterol biosynthesis by inhibiting squalene epoxidase. It has also been reported
to distort the hyphae and to stunt mycelial growth in susceptible organisms.

 


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Payment and delivery
Payment Terms: Western Union, Money Gram, T/T, Bank Transfer;Bitcoin
Delivery time: 1-3 working days after confirming the payment
Delivery  Door to Door,safety gurantee
4 big express: DHL, TNT, FedEx, UPS, 
Post: HKEMS, , etc.
Bulk qty for special line, guarantee safety
Packaging Details: If customer no special request, normally and safe pack.
Supply Ability: Bulk qty in stock

 


1.Delievery time: send out within 24 hours,delivery within around 1 week for sample order and 2 weeks for bulk production.

2.Quality: we strictly on selecting raw materials,raw powder ,high purity more than 99%.

3.Factory price: factory directly supply to clients,lower prices,more competitiveness. 

4.Service: accomplay customers to complete the purchase(good pre-sales service and after-sales service).Sample test (1-5kg) and OEM/ODM available.

5.Safety and Convenience: we guranteed 100% safe shipment by special lines to different countries, and double custom clearance door to door.

6.Transportation: we can also accept USPS,DHL, TNT, UPS, FEDEX, EMS.special line,sea transportation as your requirements.

7.Our strength: professional R&D technology team and equipment to keep products better and better.

8.Payment terms: Western Union,Moneygram,USDT,Bitcoin, T/T for your choices.

 

We are a professional senior member of Made-in-China.com, and we are guaranteed
in terms of product quality and credibility, and we have many years of experience in exporting and participating in foreign trade.

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More products, please contact us,

 

Moderate price will be offered to you.

 

Contact me :

Sales manager:Anna Sofia

What=s=app/Tele=gram/Tel: +86 155=1212=0776

We=chat ID:wan68na

Wi=ckr: wjadmin

Signal:+66 936689970

E=mail: wj@gzwjsw.com

 

 

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Packing & Delivery
Company Profile
Our company is located in the center of politics, military, economy, culture and science and education in South China.We are a professional manufacturer engaged in the research, development, production, sales and service of surfactants, biological agents, organic chemistry, oilfield chemicals and disinfectant raw materials.We can offer a wide range of products to meet the changing needs of the market.Custom orders are welcome.We are committed to strict quality control and thoughtful customer service, and our experienced staff are always available to discuss your requirements and ensure complete customer satisfaction.With an annual production capacity of 10,000 tons/year, we can easily meet your large orders.If you are interested in any of our products or would like to place a custom order, please contact us.We will do our best to meet your needs.
Our Advantages
Exhibition
FAQ
Q1. Can I have a sample order for your products?
A: Yes, we welcome sample order to test and check quality. Mixed samples are acceptable. We provide free samples, but the freight will be borne by you, and the cost will be returned to you or deducted from your order later.
Q2. What about the lead time?
A:Sample needs 1-3 days, mass production time needs 1-2 weeks.
Q3. Do you have any MOQ limit for order?
A: Low MOQ, 10-100g for sample checking is available
Q4. How do you ship the goods and how long does it take to arrive?
A: We usually ship by DHL, UPS, FedEx or TNT. It usually takes 3-5 days to arrive. Airline and sea shipping also optional.
Q5. How about the packing?
A: Usually we provide the packing as 25 kg / bag or carton. Of course, if you have special requirements on them, we will according to you.
Q6: how do you control quality?
A: We will make samples before mass production and start mass production after sample approval. 100% inspection during production and random inspection before packaging.
Q7: how to contact us?
A: Pls send us the product information you are interested in. You will get a reply within 24
hours.
Q8: which payment method do you accept?
A: For small orders, you can pay by wire transfer, Western Union, Moneygram transfer, Bank Tansfer, Bitcoin or Alibaba.
Q9: can you give me a discount?
A: Of course, it depends on your quantity
Q10: how to confirm product quality before placing an order?
A: you can get free samples for some products. You only need to pay for transportation or arrange express delivery to take samples for us. You can send us your product specifications and requirements. We will make products according to your requirements.
Q11: how do you deal with quality complaints?
A: first of all, our quality control will reduce the quality problem to nearly zero. If the actual quality problem is caused by
us, we will send you free goods for replacement or refund.
Q12: Are you trading company or manufacturer?
A: We are chemical factory in China. So we can provide wholesale price.

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