Safe and Fast Delivery, Free Customs Clear DDP 99% high purity Dacarbazine powder CAS 4342-03-4

4342-03-4 Dacarbazine

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Biological Agents   Chemical Enterprise

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Safe and Fast Delivery, Free Customs Clear DDP 99% high purity Dacarbazine powder CAS 4342-03-4

Dacarbazine is a new type of purine precursor-class anticancer drug. It can interfere with purine biosynthesis, while having the role of alkylating agents together. It has inhibitory effects on mice sarcoma-180, lung cancer-755, melanoma B16 and leukemia L-1210. It takes effects on the G2 phase of the cell cycle with its main impact on RNA and protein synthesis, followed by DNA. Its oral absorption is not complete with large individual differences. After single-time intravenous injection, it reaches peak within 30 min and disappear after 6h. During the 6 h, the drug excreted from urine account for 30% of the total administered dose. It can’t penetrate through the blood-brain barrier.
Clinical cases mainly apply the citrate salt form of dacarbazine that appears as a white crystalline powder. Its aqueous solution exhibits strong acidicity with the pH being 1.9 to 2.3. It is mainly used for the treatment of malignant melanoma with a better efficacy than hydroxyurea. When being used in combination with vinblastine and BCNU, its efficacy can be improved. It can also be applied to the treatment of squamous cell carcinoma and undifferentiated carcinoma, leiomyosarcoma, fibrosarcoma and so on. However, it is ineffective in treating digestive tract tumors.

Melting point  199-205°C
Boiling point  315.57°C (rough estimate)
density  1.3206 (rough estimate)
refractive index  1.7500 (estimate)
storage temp.  2-8°C
solubility  Slightly soluble in water and in anhydrous ethanol, practically insoluble in methylene chloride.
form  powder
pka pKa 4.42 (Uncertain)
color  Off-White to Light Yellow

 

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