High Quality Terbinafine/Terbinafina/Terbinafin Hydrochloride CAS: 78628-80-5/91161-71-6 Powder Terbinafine freebase Safe Shipping

91161-71-6 Terbinafine /whatsapp +8615512120776

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Basic information of Fast and safe shipment Terbinafine CAS 91161-71-6

Terbinafine (Lamisil) is a second-generation allylamine that is related to naftifine; however, it is 10 to 100 times more potent in vitro. It is fungicidal, whereas griseofulvin, ketoconazole, itraconazole, and other azole derivatives are all fungistatic. Because it is fungicidal, duration of therapy is shorter, and relapse rates are less than with other oral or topical therapies. Terbinafine acts by inhibiting squalene epoxidase and thereby decreasing synthesis of ergosterol, an essential component of fungal cell membranes. It is highly lipophilic and concentrates in the stratum corneum, sebum, and hair follicles. Slightly better cure rates are attained with b.i.d. than with daily dosing.

CAS: 91161-71-6
MF: C21H25N
MW: 291.43
EINECS: 618-706-8

The packages will pass the customs 100% and it will be sent in your hands safely within 12-15 days.
High Quality Terbinafine/Terbinafina/Terbinafin Hydrochloride CAS: 78628-80-5/91161-71-6 Powder, Safe ShippingHigh Quality Terbinafine/Terbinafina/Terbinafin Hydrochloride CAS: 78628-80-5/91161-71-6 Powder, Safe ShippingHigh Quality Terbinafine/Terbinafina/Terbinafin Hydrochloride CAS: 78628-80-5/91161-71-6 Powder, Safe Shipping

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Related product :Terbinafine HCL 78628-80-5
Specification of Analysis

Product name Terbinafine HCL
CAS No. 78628-80-5 Outer Packing 25KG/drum
Production date 2021.05.14 Shelf life 2023.05.15
Standard adopted EP7
Items of analysis Specification Results
Appearance White or off-white powder Comply
Identification IR, CHLORIDE Comply
Solubility Very slightly or slightly soluble in water, Comply
Impurity B ≤0.15% 0.01%
Impurity E ≤0.05% Comply
Single unknown impurity ≤0.10% 0.05%
Total impurities ≤0.30% 0.15%
Loss on drying ≤0.5% 0.17%
Heavy metals ≤20ppm Comply
PH 3.0~4.5 3.68
Residue on ignition ≤0.1% 0.05%
i-propanol ≤ 2000 ppm Comply
  ≤ 2000 ppm Comply
Assay 99~101% (Titration) 99.92%
Storage Keep tightly closed. Store in a cool dry place. Keep tightly closed. Store in a cool dry place
Conclusion Qualified


Terbinafine hydrochloride (TDT 067 hydrochloride) is an antifungal medication used to treat fungal infections. It is a potent non-competitive inhibitor of squalene epoxidase from Candida with a Ki of 30 nM.

Terbinafine has a primary fungicidal action in vitro against most fungal pathogens, including dermatophytes, and dimorphic and filamentous fungi. Terbinafine specifically inhibits fungal ergosterol biosynthesis at the point of squalene epoxidation. The treated fungal cells rapidly accumulate tlic intermediate squalene and become deficient in the end-product of the pathway, ergosterol.
Terbinafine is not only active after topical application but is very effective in experimental dermatophytoses following oral administration. In fungi infected guinea-pigs, the skin temperature dropps dramatically after the fourth treatment of terbinafine

Function

1. Terbinafine is mainly effective on the dermatophyte group of fungi.
2. As a 1% cream or powder, it is used topically for superficial skin infections such as jock itch (tinea cruris), athlete's foot (tinea pedis), and other types of ringworm (tinea corporis). Terbinafine cream works in about half the time required by other antifungals.
3. Oral 250-mg tablets are often prescribed for the treatment of onychomycosis, a fungal nail infection, typically by a dermatophyte or Candida species. Fungal nail infections are located deep under the nail in the cuticle to which topically applied treatments are unable to penetrate in sufficient amounts. The tablets may, rarely, cause hepatotoxicity, so patients are warned of this and may be monitored with liver function tests. Alternatives to oral administration have been studied.
4. Terbinafine hydrochloride may induce or exacerbate subacute cutaneous lupus erythematosus. Persons with lupus erythematosus should first discuss possible risks with their doctor before initiation of therapy.

Application                              

Anti-fungal, onychomycosis
Anti-tumor and anti-angiogenic 
For athlete's foot,Onychomycosis, tinea, jock itch, tinea versicolor caused by fungi have a significant effect
For bronchial asthma, asthmatic bronchitis and emphysema

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Our company is located in the center of politics, military, economy, culture and science and education in South China.We are a professional manufacturer engaged in the research, development, production, sales and service of surfactants, biological agents, organic chemistry, oilfield chemicals and disinfectant raw materials.We can offer a wide range of products to meet the changing needs of the market.Custom orders are welcome.We are committed to strict quality control and thoughtful customer service, and our experienced staff are always available to discuss your requirements and ensure complete customer satisfaction.With an annual production capacity of 10,000 tons/year, we can easily meet your large orders.If you are interested in any of our products or would like to place a custom order, please contact us.We will do our best to meet your needs.

FAQ

Q1. Can I have a sample order for your products?
A: Yes, we welcome sample order to test and check quality. Mixed samples are acceptable. We provide free samples, but the freight will be borne by you, and the cost will be returned to you or deducted from your order later.
Q2. What about the lead time?
A:Sample needs 1-3 days, mass production time needs 1-2 weeks.
Q3. Do you have any MOQ limit for order?
A: Low MOQ, 10-100g for sample checking is available
Q4. How do you ship the goods and how long does it take to arrive?
A: We usually ship by DHL, UPS, FedEx or TNT. It usually takes 3-5 days to arrive. Airline and sea shipping also optional.
Q5. How about the packing?
A: Usually we provide the packing as 25 kg / bag or carton. Of course, if you have special requirements on them, we will according to you.
Q6: how do you control quality?
A: We will make samples before mass production and start mass production after sample approval. 100% inspection during production and random inspection before packaging.
Q7: how to contact us?
A: Pls send us the product information you are interested in. You will get a reply within 24hours.
Q8: which payment method do you accept?
A: For small orders, you can pay by wire transfer, Western Union, Moneygram transfer, Bank Tansfer, Bitcoin or Alibaba.
Q9: can you give me a discount?
A: Of course, it depends on your quantity
Q10: how to confirm product quality before placing an order?
A: you can get free samples for some products. You only need to pay for transportation or arrange express delivery to take samples for us. You can send us your product specifications and requirements. We will make products according to your requirements.
Q11: how do you deal with quality complaints?
A: first of all, our quality control will reduce the quality problem to nearly zero. If the actual quality problem is caused by
us, we will send you free goods for replacement or refund.
Q12: Are you trading company or manufacturer?
A: We are chemical factory in China. So we can provide wholesale price.

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