Highest Quality 5875-06-9 Proparacaine Hydrochloride in Stock

5875-06-9 Proparacaine hydrochloride

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Highest Quality 5875-06-9 Proparacaine Hydrochloride in Stock


Product name Proparacaine HCL
Other name Proparacaine hydrochloride
CAS register number 5875-06-9
EINECS 227-541-7
Molecular formula C16H27ClN2O3
Molecular weight 330.85
Assay 98.5%
Appearance White crystalline powder
Package 1kg/aluminium foil bag or as required
Usage can be used as pharmaceutical material

Highest Quality 5875-06-9 Proparacaine Hydrochloride in StockProparacaine Hydrochloride Ophthalmic Solution is a rapid acting local anesthetic suitable for ophthalmic use. With a single drop, the onset of anesthesia begins within 30 seconds and persists for 15 minutes or longer.

The main site of anesthetic action is the nerve cell membrane where proparacaine interferes with the large transient increase in the membrane permeability to sodium ions that is normally produced by a slight depolarization of the membrane. As the anesthetic action progressively develops in a nerve, the threshold for electrical stimulation gradually increases and the safety factor for conduction decreases; when this action is sufficiently well developed, block of conduction is produced.

The exact mechanism whereby proparacaine and other local anesthetics influence the permeability of the cell membrane is unknown; however, several studies indicate that local anesthetics may limit sodium ion permeability by closing the pores through which the ions migrate in the lipid layer of the nerve cell membrane. This limitation prevents the fundamental change necessary for the generation of the action potential.

Proparacaine Hydrochloride Ophthalmic Solution is indicated for topical anesthesia in ophthalmic practice. Representative ophthalmic procedures in which the preparation provides good local anesthesia include measurement of intraocular pressure (tonometry), removal of foreign bodies and sutures from the cornea, conjunctival scraping in diagnosis and gonioscopic examination; it is also indicated for use as a topical anesthetic prior to surgical operations such as cataract extraction.

Highest Quality 5875-06-9 Proparacaine Hydrochloride in Stock

Items Standards Results
Appearance White to light yellow crystalline powder Complies
Identification It should be Nitrogen base reaction Complies
By UV Complies
Should display the reaction of chloride differentiated Complies
Solubility Should dissolved in water, warm ethanol and methanol, insoluble in ether and benzene, the solution is neutral to litmus Complies
Melting Point 178ºC~185ºC 180.3~182.1ºC
Loss on Drying ≤ 0.50% 0.14%
Residue on Ignition ≤ 0.15% 0.03%
Residual Solvents DMF: ≤880ppm ND
Ethanol: ≤5000ppm ND
Acetone: ≤5000ppm ND
Isopropanol: ≤5000ppm ND
Toluene: ≤890ppm ND
Methanol: ≤3000ppm ND
Related Substances If the impurities are detected, then the total amount of the impurities should be not more than 2.0%. Complies
Assay                  (on the anhydrous basis) 97.0%~103.0% 99.67%
Reference Standard USP35 Standard
Conclusion The product complied to USP35 standard.
Storage Preserve in tight,light-resistant containers in a cool place

Highest Quality 5875-06-9 Proparacaine Hydrochloride in Stock



99% Purity Xylometazoline HCl / Xylometazoline Hydrochloride CAS 1218-35-5



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